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10.1002/ccd.26110 http://scihub22266oqcxt.onion/10.1002/ccd.26110 C4769123!4769123!26309050     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26309050&cmd=llinks): Failed to open stream: HTTP request failed! 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Safety of an Abbreviated Duration of Dual Antiplatelet Therapy (? Six Months) Following Second-Generation Drug-Eluting Stents for Coronary Artery Disease: A Systematic Review and Meta-Analysis of Randomized Trials |pdf=|usr=}}{{26309050}} gab.com Text Safety of an Abbreviated Duration of Dual Antiplatelet Therapy ( Six Months) Following Second-Generation Drug-Eluting Stents for Coronary Artery Disease: A Systematic Review and Meta-Analysis of Randomized Trials JO: Catheter Cardiovasc Interv http://www.kidney.de/pget.php?&tw=1&pmid=26309050 #FOAvip Background: Dual antiplatelet therapy (DAPT) is recommended for ?12 months following coronary drug-eluting stents (DES) to reduce risk of major adverse ischemic events. Randomized trials suggest an abbreviated DAPT duration (?6 months) is adequately protective. However, these trials are individually underpowered to detect differences in rare but serious events such as stent thrombosis (ST). Objectives: We performed a meta-analysis of published randomized trials to define the impact of abbreviated DAPT (?6 months) on death, myocardial infarction (MI), stent thrombosis(ST) and bleeding complications compared to standard-duration DAPT (?12 months). Methods: Seven randomized controlled trials comparing abbreviated vs. standard DAPT regimens following DES use were identified by 2 independent investigators. Study characteristics were reviewed and clinical endpoint data were abstracted and analyzed in aggregate using fixed and random-effects models. Results: The 7 trials included 15,874 randomized patients. Second-generation DES were used in most patients. Compared to standard-duration DAPT, abbreviated DAPT was not associated with an increase in mortality (OR 0.93; CI: 0.73 to 1.17; p = 0.52), MI (OR 1.14; CI: 0.89 to 1.45; p = 0.30) or ST (OR 1.25; CI: 0.81 to 1.93; p = 0.31). Abbreviated DAPT was associated with significantly fewer major bleeding complications (OR 0.52; CI: 0.34 to 0.82; p = 0.005). The results were consistent between fixed and random-effects models, with no heterogeneity. Sensitivity analyses adjusting for inclusion of bare metal stents, 1st generation DES and/or abbreviated DAPT regeimens of 3 months resulted in similar conclusions. Conclusions: In a meta-analysis of >15,000 patients primarily treated with second-generation DES, abbreviated-duration DAPT (?6 months) was associated with a significant reduction in major bleeding complications with no evidence of a significant increase in risk of death, MI or ST. Accordingly, abbreviated DAPT should be strongly considered for patients receiving second generation DES. Twit Text FOAVip Safety of an Abbreviated Duration of Dual Antiplatelet Therapy ( Six Months) Following Second-Generation Drug-Eluting Stents for Coronary Artery Disease: A Systematic Review and Meta-Analysis of Randomized Trials ????Catheter Cardiovasc Interv http://www.kidney.de/pget.php?&tw=1&pmid=26309050 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26309050 #FOAvip English Wikipedia <ref>{{Cite pmid|26309050}}</ref> Safety of an Abbreviated Duration of Dual Antiplatelet Therapy (? Six Months) Following Second-Generation Drug-Eluting Stents for Coronary Artery Disease: A Systematic Review and Meta-Analysis of Randomized Trials #MMPMID26309050 Ziada KM; Abdel-Latif AK; Charnigo R; Moliterno DJ Catheter Cardiovasc Interv 2016[Mar]; 87 (4): 722-32 PMID26309050show ga Background: Dual antiplatelet therapy (DAPT) is recommended for ?12 months following coronary drug-eluting stents (DES) to reduce risk of major adverse ischemic events. Randomized trials suggest an abbreviated DAPT duration (?6 months) is adequately protective. However, these trials are individually underpowered to detect differences in rare but serious events such as stent thrombosis (ST). Objectives: We performed a meta-analysis of published randomized trials to define the impact of abbreviated DAPT (?6 months) on death, myocardial infarction (MI), stent thrombosis(ST) and bleeding complications compared to standard-duration DAPT (?12 months). Methods: Seven randomized controlled trials comparing abbreviated vs. standard DAPT regimens following DES use were identified by 2 independent investigators. Study characteristics were reviewed and clinical endpoint data were abstracted and analyzed in aggregate using fixed and random-effects models. Results: The 7 trials included 15,874 randomized patients. Second-generation DES were used in most patients. Compared to standard-duration DAPT, abbreviated DAPT was not associated with an increase in mortality (OR 0.93; CI: 0.73 to 1.17; p = 0.52), MI (OR 1.14; CI: 0.89 to 1.45; p = 0.30) or ST (OR 1.25; CI: 0.81 to 1.93; p = 0.31). Abbreviated DAPT was associated with significantly fewer major bleeding complications (OR 0.52; CI: 0.34 to 0.82; p = 0.005). The results were consistent between fixed and random-effects models, with no heterogeneity. Sensitivity analyses adjusting for inclusion of bare metal stents, 1st generation DES and/or abbreviated DAPT regeimens of 3 months resulted in similar conclusions. Conclusions: In a meta-analysis of >15,000 patients primarily treated with second-generation DES, abbreviated-duration DAPT (?6 months) was associated with a significant reduction in major bleeding complications with no evidence of a significant increase in risk of death, MI or ST. Accordingly, abbreviated DAPT should be strongly considered for patients receiving second generation DES. äSafety of an Abbreviated Duration of Dual Antiplatelet Therapy (? Six (epmc).pdf DeepDyve Pubget Overpricing